Actd3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Actd3^DBA/2J
• Name: activity-distance traveled 3; DBA/2J
• MGI ID: MGI:2156059
• QTL: Actd3 Location: Chr5:113320385-113320533 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 55.39 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased locomotor activity compared to C57BL/6J (J:65696)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:65696

A 2-tiered approach was used to identify QTLs associated with basal locomotor activity in rodents, as measured by distance traveled in an open field test during a 20 minute time interval. First, 25 BXD recombinant inbred (RI) strains were typed for 400 polymorphic markers at an average spacing of 4 cM to identify potential QTLs (B = C57BL/6J, D = DBA/2J). Second, potential QTLs were confirmed by screening approximately 500 animals from a (C57BL/6J x DBA/2J)F2 intercross. Parental strain C57BL/6J exhibits more activity compared to parental strain DBA/2J. A locus on mouse chromosome 1, Actd1, was significantly associated with locomotor activity in both the RI strains and (C57BL/6J x DBA/2J)F2 intercross. Actd1 maps to approximately 65 cM (LOD=10.5) on mouse Chromosome 1 with a QTL range of 40 cM - 90 cM. QTLs on mouse chromosome 5, Actd2 at 9 cM (P<0.001 at D5Mit72) and Actd3 at 61 cM (P<5 x 0.0001 at D5Mit278), were identified and confirmed, and a QTL on mouse Chromosome 9, Actd4 at 28 cM (P<2 x 0.0001 at D9Mit94), was identified and confirmed. C57BL/6J-derived alleles increase locomotor activity at Actd1, Actd2, and Actd3, while DBA/2J-derived alleles increase locomotor activity at Actd4.

References

• Original: J:65696 Koyner J, et al., Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross. Behav Genet. 2000 May;30(3):159-70
• All: 1 reference(s)