Bmd2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bmd2^C57BL/6J
• Name: bone mineral density 2; C57BL/6J
• MGI ID: MGI:2156068
• QTL: Bmd2 Location: Chr5:55388334-100455525 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 30.56 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone mineral density compared to CAST/Ei. (J:58152)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58152

Bone mineral density (Bmd2) was measured as a quantitative trait (QTL) in a genome wide scan of 711 F2 mice in a genetic intercross involving C57BL/6J and CAST/Ei mice. C57BL/6J females express a low mineral bone density phenotype, alternatively CAST/Ei male express a high mineral bone density. Regression analysis was informative to show Bmp2 significantly associated with marker D5Mit112 within a defined QTL region bounded by markers D5Mit254 and D5Mit89. Due to the large size of the QTL region the authors did not suggest any candidate loci encoding for the Bone mineral density phenotype.

References

• Original: J:58152 Beamer WG, et al., Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome. 1999 Nov;10(11):1043-9
• All: 2 reference(s)