Szs6^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Szs6^C57BL/6J
• Name: seizure susceptibility 6; C57BL/6J
• MGI ID: MGI:2156080
• QTL: Szs6 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 44.32 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased seizure susceptibility compared to DBA/2J. (J:56630)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:56630

DBA/2J and C57BL/6J mice exhibit differential sensitivity to seizure induced by pentylenetetrazol (PTZ) with DBA/2J mice being sensitive and C57BL/6J mice being relatively resistant. PTZ-induced seizure responses were studied in DBA/2J, C57BL/6J, (DBA/2Jx C57BL/6J)F1 and (DBA/2J x C57BL/6J)F2 intercross mice. QTL mapping and complementary statistical analysis identified a locus on Chromosome 5 near D5Mit398 (LOD = 4.18 with 5.8% of total variance explained). Relevant candidate genes near this locus include Gabra2 and Gabra1. Szs6 is derived from a C57BL/6J-derived susceptibility allele.

References

• Original: J:56630 Ferraro TN, et al., Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci. 1999 Aug 15;19(16):6733-9
• All: 1 reference(s)