Pten^tm1Hwu
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Hwu
• Name: phosphatase and tensin homolog; targeted mutation 1, Hong Wu
• MGI ID: MGI:2156086
• Synonyms: Pten^ex5lox, PTEN^F, Pten^fl, Pten^flox, Pten^flx, Pten^fx, Pten^lox, Pten^loxp
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Hwu page

Ovary tumors in Pik3ca^tm1.1Waph/Pik3ca^tm1.1Waph Pten^tm1Hwu/Pten^tm1Hwu mice

Show the 16 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75117
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked hygromycin resistance cassette was inserted 5' to exon 5, and a single loxP site was inserted 3' to exon 5, which encodes the phosphatase domain. The hygromycin cassette was removed in ES cells by transient Cre recombinase expression prior to the production of chimeric mice, leaving a single loxP site in place of the cassette. These insertions do not appear to have any effect on the normal function of the gene. (J:75117)

Disease models

Expression

In Mice Carrying this Mutation:	347 assay results 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	91 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1Hwu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 16 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: PTEN Hamartoma Tumor Syndrome (see OMIM:601728 Phosphatase And Tensin Homolog; PTEN) J:199362

References

• Original: J:75117 Lesche R, et al., Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis. 2002 Feb;32(2):148-9
• All: 769 reference(s)