Aeyo^C57BL/6By
QTL Variant Detail

Summary

• QTL variant: Aeyo^C57BL/6By
• Name: age of eyelid opening; C57BL/6By
• MGI ID: MGI:2156123
• QTL: Aeyo Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 50.64 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6By

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele increases the age of eyelid opening compared to NZB/BlNJ. (J:53794)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53794

Nineteen measures of sensorial, motor and body weight were subject to analysis in 389 female and male mice derived from reciprocal F1 and F2 mating of strains C57BL6/By and NZB/BlNJ . These traits were mapped via QTL analysis. In total 36 traits were mapped to chromosomes of which a number reached a threshold LOD score of 3.13 and were thus concidered significant. One such QTL, eyelid opening (Aeyo), mapped with mouse Chromosome 5 marker D5Mit10 with a LOD score of 4.45. C57BL/6By-derived alleles confer increased age of eyelid opening with dominant inheritance at Aeyo.

A suggestive QTL for age of eyelid opening mapped to 71 cM on mouse Chromosome 13 near D13Mit78 (LOD=2.19). NZB/BlNJ-derived alleles confer increased age of eyelid opening with dominant inheritance at this locus.

References

• Original: J:53794 Le Roy I, et al., Preweanling sensorial and motor development in laboratory mice: quantitative trait loci mapping. Dev Psychobiol. 1999 Mar;34(2):139-58
• All: 1 reference(s)