Bwefm^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Bwefm^NZB/BlNJ
• Name: body weight females and males day 10; NZB/BlNJ
• MGI ID: MGI:2156130
• QTL: Bwefm Location: Chr5:126439348-126439459 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 64.81 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at day 10 compared to C57BL/6By. (J:53794)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53794

Nineteen measures of sensorial, motor and body weight were subject to analysis in 389 female and male mice derived from reciprocal F1 and F2 mating of strains C57BL6/By and NZB/BlNJ . These traits were mapped via QTL analysis. In total 36 traits were mapped to chromosomes of which a number reached a threshold LOD score of 3.13 and were thus concidered significant. One such QTL for body weight day 10 female and male (bwefm) mapped with mouse Chromosome 5 marker D5Mit213 with a LOD score of 5.11. NZB/BlNJ-derived alleles confer dominantly inherited increased body weight at day 10 animals at this locus.

A suggestive locus mapped to 58 cM on mouse Chromosome 2 near D2Mit42 (LOD=2.39.) C57BL/6By-derived alleles confer dominantly increased body weight at day 10 at this locus.

References

• Original: J:53794 Le Roy I, et al., Preweanling sensorial and motor development in laboratory mice: quantitative trait loci mapping. Dev Psychobiol. 1999 Mar;34(2):139-58
• All: 1 reference(s)