Aicda^tm1Hon
Targeted Allele Detail

Summary

• Symbol: Aicda^tm1Hon
• Name: activation-induced cytidine deaminase; targeted mutation 1, Tasuku Honjo
• MGI ID: MGI:2156156
• Synonyms: AID-
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73659
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2 and part of exon 3, which encodes the cytidine deaminase motif. RT-PCR studies of cultured spleen cells did not detect wild-type transcripts in homozygous mutant mice. (J:73659)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Aicda^tm1Hon

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:73659 Muramatsu M, et al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000 Sep 1;102(5):553-63
• All: 230 reference(s)