Dssc1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Dssc1^C57BL/6J
• Name: dextran sodium sulfate induced colitis QTL1; C57BL/6J
• MGI ID: MGI:2156163
• QTL: Dssc1 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 71.08 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased colitis susceptibility compared to C3H/HeJ. (J:52852)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Dssc1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52852

The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) was investigated by crossing susceptible C3H/HeJ mice to partially resistant C57BL/6J mice. 86 (C3H/HeJ x C57BL/6J)F2 mice and 90 [(C3H/HeJ x C57BL/6J) x C57BL/6J]N2 backcross mice were analyzed for the presence of QTLs influencing DSS-induced colitis. An additive QTL on mouse Chromosome 5 between D5Mit188 and D5Mit285 (susceptibility marked by the B6 allele at D5Mit216) was significantly linked to several of the colon subphenotypes like severity, hyperplasia, ulceration, and % area involved. The confidence level for linkage of QTL to markers on Chromosome 5 exceeded the threshold for declaring significant linkage (P = 0.0000137). Possible candidate genes in the region include Selp1 and Pdgfa.

References

• Original: J:52852 Mahler M, et al., Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics. 1999 Jan 15;55(2):147-56
• All: 1 reference(s)