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Adam3tm1Pmkf
Targeted Allele Detail
Summary
Symbol: Adam3tm1Pmkf
Name: ADAM metallopeptidase domain 3; targeted mutation 1, Paul Primakoff
MGI ID: MGI:2156167
Synonyms: cyritestin -, Cyrn -
Gene: Adam3  Location: Chr8:25167241-25215868 bp, - strand  Genetic Position: Chr8, 13.09 cM, cytoband A2
Alliance: Adam3tm1Pmkf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69282
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exon 14 was replaced with a neomycin selection cassette. Western blots on sperm extracts confirmed the absence of the full length protein in homozygous mice. (J:69282)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam3 Mutation:  61 strains or lines available
References
Original:  J:69282 Nishimura H, et al., Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta. Dev Biol. 2001 May 1;233(1):204-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory