Adam3^tm1Pmkf
Targeted Allele Detail

Summary

• Symbol: Adam3^tm1Pmkf
• Name: ADAM metallopeptidase domain 3; targeted mutation 1, Paul Primakoff
• MGI ID: MGI:2156167
• Synonyms: cyritestin -, Cyrn -
• Gene: Adam3 Location: Chr8:25167241-25215868 bp, - strand Genetic Position: Chr8, 13.09 cM, cytoband A2
• Alliance: Adam3^tm1Pmkf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 14 was replaced with a neomycin selection cassette. Western blots on sperm extracts confirmed the absence of the full length protein in homozygous mice. (J:69282)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam3 Mutation: 61 strains or lines available

References

• Original: J:69282 Nishimura H, et al., Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta. Dev Biol. 2001 May 1;233(1):204-13
• All: 5 reference(s)