Adamts1^tm1Hku
Targeted Allele Detail

Summary

• Symbol: Adamts1^tm1Hku
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 1; targeted mutation 1, Hiroki Kurihara
• MGI ID: MGI:2156168
• Synonyms: ADAMTS-1 -
• Gene: Adamts1 Location: Chr16:85590715-85600001 bp, - strand Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
• Alliance: Adamts1^tm1Hku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62260
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.6kb genomic fragment containing exons 2-4 was replaced with a neomycin selection cassette. RT-PCR analysis confirmed that the encoded transcript was not present in detectable levels in RNA derived from kidney of homozygous mice. (J:62260)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts1 Mutation: 66 strains or lines available

References

• Original: J:62260 Shindo T, et al., ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function [see comments]. J Clin Invest. 2000 May;105(10):1345-52
• All: 2 reference(s)