Lamc1^Gt(Ex183)Byg
Gene trapped Allele Detail

Summary

• Symbol: Lamc1^Gt(Ex183)Byg
• Name: laminin, gamma 1; gene trap Ex183, BayGenomics
• MGI ID: MGI:2156186
• Synonyms: Lamc1^{Gt(pGT1.8TM)183Wcs}
• Gene: Lamc1 Location: Chr1:153094668-153208532 bp, - strand Genetic Position: Chr1, 65.3 cM
• Alliance: Lamc1^Gt(Ex183)Byg page

Mutation origin

• Mutant Cell Line: Ex183
• Germline Transmission: Earliest citation of germline transmission: J:70273
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Mutation details: Gene trap vector pGT1.8TM was inserted into the gene. The fusion protein conatins the first 1091 amino acids of the locus, including the entire short arm and the first 63 amino acids of its helical domain II followed by the transmembrane domain and Betageo from the vector. Betagal expression was detected in neurons of many regions, including the cerebral cortex and hippocampal formation. (J:85792)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  Ex183	CC144400 ; (MGI Seq Detail)	5' RACE	Chr1:153115000-153116240 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  67 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamc1 Mutation: 143 strains or lines available

References

• Original: J:70273 Mitchell KJ, et al., Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001 Jul;28(3):241-9
• All: 3 reference(s)