Lrp6^Gt(Ex187)Byg
Gene trapped Allele Detail

Summary

• Symbol: Lrp6^Gt(Ex187)Byg
• Name: low density lipoprotein receptor-related protein 6; gene trap Ex187, BayGenomics
• MGI ID: MGI:2156191
• Synonyms: lrp6-, Lrp6^betageo, Lrp6^{Gt(pGT1.8TM)187Wcs}, Lrp6^lacZ
• Gene: Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
• Alliance: Lrp6^Gt(Ex187)Byg page

Lrp6^Cd/Lrp6^Gt(Ex187)Byg mice reveal a range of phenotypes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: Ex187
• Germline Transmission: Earliest citation of germline transmission: J:64989
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Mutation details: Insertion of a gene trap vector into the gene that joined the first 321 amino acids of the encoded protein in frame to a beta-galactosidase-neomycin resistance reporter gene. Northern blot analysis demonstrated that no normal transcript was encoded by this allele. (J:64989)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  Ex187	CC144397 ; (MGI Seq Detail)	5' RACE	Chr6:134488130-134490260 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  17 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	79 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp6 Mutation: 95 strains or lines available

References

• Original: J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
• All: 44 reference(s)