Gpc3^Gt(Ex136)Byg
Gene trapped Allele Detail

Summary

• Symbol: Gpc3^Gt(Ex136)Byg
• Name: glypican 3; gene trap Ex136, BayGenomics
• MGI ID: MGI:2156194
• Synonyms: Gpc3^{Gt(pGT1.8TM)136Wcs}, Gpc3^{TgN(betageo)ex136Ska}
• Gene: Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
• Alliance: Gpc3^Gt(Ex136)Byg page

Mutation origin

• Mutant Cell Line: Ex136
• Germline Transmission: Earliest citation of germline transmission: J:64330
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1tfr
• Mutation details: The gene trap vector pGT1tfr was inserted into intron 2. Western blot analysis on purified proteoglycan extracts derived from E16.5 liver of male hemizygous mice confirmed that no detectable protein is produced from this allele. (J:64330)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  Ex136	CC144541 ; (MGI Seq Detail)	5' RACE	ChrX:51671674-51702550 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  28 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpc3 Mutation: 18 strains or lines available

References

• Original: J:70273 Mitchell KJ, et al., Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001 Jul;28(3):241-9
• All: 3 reference(s)