Fat1^{Gt(GST070)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Fat1^{Gt(GST070)Byg}
• Name: FAT atypical cadherin 1; gene trap GST070, BayGenomics
• MGI ID: MGI:2156198
• Synonyms: Fat1^{Gt(pGT1.8TM)70Wcs}
• Gene: Fat1 Location: Chr8:45388484-45505294 bp, + strand Genetic Position: Chr8, 24.81 cM
• Alliance: Fat1^{Gt(GST070)Byg} page

Mutation origin

• Mutant Cell Line: GST070
• Germline Transmission: Earliest citation of germline transmission: J:70273
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Gene trap vector pGT1.8TM was inserted into the gene.
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  GST070	CC144812 ; (MGI Seq Detail)	5' RACE	Chr8:45406374-45406509 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  63 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Fat1^Gt(GST070)Byg/Fat1^Gt(GST070)Byg	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
mortality/aging	√
neonatal lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fat1 Mutation: 208 strains or lines available

References

• Original: J:70273 Mitchell KJ, et al., Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001 Jul;28(3):241-9
• All: 2 reference(s)