Lprm4^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Lprm4^MRL/MpJ
• Name: lymphoproliferation modifier 4; MRL/MpJ
• MGI ID: MGI:2156224
• QTL: Lprm4 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to splenomegaly compared to C3H/HeJ. (J:44625)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44625

82 MRL/MpJ-Tnfrsf6^lpr x (MRL/MpJ-Tnfrsf6^lpr x C3.MRL-Tnfrsf6^lpr)F1 backcross animals were used to identify QTLs modifying the lpr (lymphoproliferation) mutant phenotype. Genotyping was performed with 76 microsatellite markers covering 84% of the mouse genome at an average spacing of 20 cM. The MRL/MpJ-Tnfrsf6^lpr parental strain is susceptible to developing glomerulonephritis (98.2%) and vasculitis (86%) whereas the C3.MRL-Tnfrsf6^lpr strain is resistant (0%) for both phenotypes. (MRL/MpJ-Tnfrsf6^lpr x C3.MRL-Tnfrsf6^lpr)F1 animals are resistant to glomerulonephritis (3%) and vasculitis (18%) development. Both strains exhibit lymph node swelling and splenomegaly in varying degrees. A QTL associated with vasculitis susceptibility, Lprm1 (P = 0.0009 at D4Mit178; 35.5 cM), maps to mouse chromosome 4 from 34 cM - 36 cM. MRL/MpJ-Tnfrsf6^lpr-derived alleles contribute recessively inherited susceptibility to vasculitis at this locus. However, MRL/MpJ-Tnfrsf6^lpr-derived alleles at Lprm2 (P = 0.0001 at D3Mit16; 66.2 cM), a QTL mapping to mouse chromosome 3 from 64 cM - 66 cM, confers female-specific recessively inherited vasculitis resistance. A possible candidate gene for Lprm1 is Tlr4 (the lps gene) at 33 cM. Lprm1 also maps near Nba1 (Drake, J:23719) and Sle2 (Morel, J:25006). Lprm3 (P = 0.0004 at D14Mit195; 44.3 cM), a QTL associated with glomerulonephritis resistance, maps to mouse chromosome 14 from 30 cM - 63 cM. MRL/MpJ-Tnfrsf6^lpr-derived alleles at this locus confer recessively inherited glomerulonephritis resistance. Lprm4 (P = 0.0006 at D5Mit23; 54 cM) is associated with susceptibility to splenomegaly and maps to mouse chromosome 5 from 41 cM - 54 cM. MRL/MpJ-Tnfrsf6^lpr-derived alleles at this locus confer recessively inherited splenomegaly susceptibility. Lprm5 (P = 0.0001 at D16Mit3; 21 cM) is associated with anti-dsDNA antibody titer and maps to mouse chromosome 16 from 21 cM-38 cM. MRL/MpJ-Tnfrsf6^lpr-derived alleles at this locus confer recessively inherited high antibody titers.

References

• Original: J:44625 Wang Y, et al., Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol. 1997 Dec;151(6):1791-8
• All: 1 reference(s)