Skts3^NIH/Ola
QTL Variant Detail

Summary

• QTL variant: Skts3^NIH/Ola
• Name: skin tumor susceptibility 3; NIH/Ola
• MGI ID: MGI:2156251
• QTL: Skts3 Location: Chr5:38667295-38667403 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 20.61 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NIH/Ola

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:27733

Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH female x M. spretus male)F1 female mice mated back to NIH male mice. Parental strain M. spretus is resistant to skin papilloma formation compared toparental strain NIH. 133 microsatellite markers were screened. Using MAPMAKER/QTL, significant linkage (Mann-Whitney U test) of Skts3 with D5Mit77 (24 cM, lod 3.71) was observed on mouse Chromosome 5. Multiple regression analysis supports the evidence fora locus on mouse Chromosome 5. Linkage to reduced tumor progression mapped to 5 cM near D5Mit1 (lod 4.13). This locus may be identical to Skts3. Potential candidate genes found near this locus are Il6 (17 cM) and Fgfr3 (20 cM).

References

• Original: J:27733 Nagase H, et al., Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet. 1995 Aug;10(4):424-9
• All: 1 reference(s)