Idd20^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Idd20^C3H/HeJ
• Name: insulin dependent diabetes susceptibility 20; C3H/HeJ
• MGI ID: MGI:2156392
• QTL: Idd20 Location: Chr6:92016931-92693678 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers insulin dependent diabetes resistance compared to NOD/Lt. (J:69992)
• Inheritance: Recessive

Notes

Idd20 appears to act epistatically to Idd19.

Trait Annotation
(using the Vertebrate Trait Ontology)

organism trait

metabolism trait

glucose metabolism trait - VT:0015088

diabetes resistant relative to NOD/Lt mice - J:69992

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69992

Newly created NOD.C3H (donor strain = C3H/HeJ-diabetes resistant, recipient strain = NOD/Lt-diabetes susceptible) recombinant congenic (RC) strains allowed finer mapping of loci linked to diabetes, Idd6 and Idd19, on mouse Chromosome 6. In addition, a novel locus, Idd20, was detected on proximal chromosome 6. NOD.C3H RC strains were derived from successive backcrossing of (NOD/Lt x C3H/HeJ)F1 females to NOD/Lt males. Phenotyping and genotyping of several NOD.C3H strains localized Idd6 (susceptibility locus) to a 3.9 cM interval between D6Mit57 and D6Mit304 (approximately 71.1 cM - 75 cM) and localized Idd19 (resistance locus) to an 11.3 cM interval between D6Mit288 and D6Mit289 (approximately 51 cM - 62.3 cM). Possible candidate genes in the region of Idd19 are Tnfrsf7, Tnfrsf1a, and Hrh1. Idd20 (susceptibility locus) maps to a 1.5 cM interval between D6Mit100 and D6Mit31 (approximately 37 cM - 38.5 cM). Idd6, Idd19, and Idd20 appear to interact epistatically.

References

• Original: J:69992 Rogner UC, et al., Three loci on mouse chromosome 6 influence onset and final incidence of type i diabetes in nod.c3h congenic strains. Genomics. 2001 Jun 1;74(2):163-71
• All: 2 reference(s)