Il12rb2^Ifnm-d
Spontaneous Allele Detail

Summary

• Symbol: Il12rb2^Ifnm-d
• Name: interleukin 12 receptor, beta 2; interferon response to microorgansisms, defective
• MGI ID: MGI:2156401
• Synonyms: Ifnm
• Gene: Il12rb2 Location: Chr6:67268302-67353172 bp, - strand Genetic Position: Chr6, 30.81 cM
• Alliance: Il12rb2^Ifnm-d page

Mutation origin

• Strain of Origin: C57BL/10ScCr

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The defective IL-12 response in C57BL/10ScCr mice has been attributed to a point mutation in the Il12rb2 gene. The substitution of a C to G at coding nucleotide 2331 creates a premature stop codon at tyrosine amino acid position 778 (p.Y778*). The resulting truncated protein lacks the C-terminal 96 amino acids of cytosplasmic domain. (J:70821)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il12rb2 Mutation: 48 strains or lines available

References

• Original: J:70821 Poltorak A, et al., A point mutation in the il-12rbeta2 gene underlies the il-12 unresponsiveness of lps-defective c57bl/10sccr mice. J Immunol. 2001 Aug 15;167(4):2106-11
• All: 6 reference(s)