Rhs1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Rhs1^C57BL/6
• Name: resistance to herpes simplex virus 1; C57BL/6
• MGI ID: MGI:2156406
• QTL: Rhs1 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers herpes resistance compared to BALB/c. (J:69352)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:69352

A locus conferring resistance to herpes simplex virus infection, Rhs1, mapped to 48.1 cM - 62.1 cM on mouse Chromosome 6 using congenic strain BALB.B6.Cmv1^s and a series of C57BL/6- and BALB/c-derived intra-NKC recombinant lines. Progenitor strain BALB/c is susceptible to infection with herpes simplex virus whereas progenitor strain C57BL/6 (B6) is resistant to infection. Congenic strain BALB.B6.Cmv1^s carries C57BL/6-derived chromosome 6 DNA spanning 60.55 cM - 65 cM on a BALB/c genetic background, and retains the herpes simplex resistant phenotype of donor strain C57BL/6. Intra-NKC recombinant lines carrying subportions of C57BL/6-derived congenic region on a BALB/c background were used to localize Rhs1 to the proximal portion of the interval.

References

• Original: J:69352 Pereira RA, et al., Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons. J Immunol. 2001 May 15;166(10):5869-73
• All: 1 reference(s)