Bpq5^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bpq5^C57BL/6J
• Name: blood pressure QTL 5; C57BL/6J
• MGI ID: MGI:2156438
• QTL: Bpq5 Location: Chr6:146330484-146330736 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 77.7 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to salt-induced hypertension compared to A/J. (J:66987)
• Inheritance: Other (see notes)

Notes

Interaction occurs between Bpq5 and Bpq6. Homozygosity for C57BL/6J-derived alleles at Bpq6 and heterozygosity at Bpq5 results in increased blood pressure.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66987

C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 Blood pressure QTLs to 5 mouse chromosomes. Beq5 interacted with Bpq6 and mapped with markers on mouse Chromosome 6. Bpq5 mapped with D6Mit15 with an F value of 13.9 and a P value of 0.00025. Suggested candidates for Bpq5 were Gnb3, Kap, Grin2b and Pthlh.

References

• Original: J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• All: 1 reference(s)