Rencd^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Rencd^CAST/EiJ
• Name: renal cystic disease severity; CAST/EiJ
• MGI ID: MGI:2156439
• QTL: Rencd Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 77.64 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased renal cystic disease severity compared to BALB/c. (J:66475)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66475

Genome scan at an average marker spacing of 25 cM was performed on F2 bpk/bpk animals from a (BALB/c-+/bpk x CAST/Ei)F2 intercross to identify QTLs involved with renal cystic disease severity. Bpk is a recessively inherited mutation that results in renalcystic disease. A significant QTL influencing renal cystic disease severity, Rencd (renal cystic disease severity), mapped to mouse Chromosome 6 near D6Mit14 (LOD = 5.5). CAST-derived alleles contribute to recessively inherited disease severity at Rencd. Suggestive QTLs mapped to mouse Chromosome 1 near D1Mit17 (LOD = 2.1), mouse Chromosome 2 near D2Mit72 (LOD = 1.2), mouse Chromosome 4 near D4Mit316 (LOD = 1.4), and mouse Chromosome 8 near D8Mit9 (LOD = 0.8). A possible epistatic interaction between Rencd and the locus at D1Mit17 was detected but did not reach statistical significance.

References

• Original: J:66475 Guay-Woodford LM, et al., Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol. 2000 Jul;11(7):1253-60
• All: 1 reference(s)