Ichs^{C57BL/6JOlaHsd}
QTL Variant Detail

Summary

• QTL variant: Ichs^{C57BL/6JOlaHsd}
• Name: immediate cutaneous hypersensitivity QTL; C57BL/6JOlaHsd
• MGI ID: MGI:2156448
• QTL: Ichs Location: Chr6:107772571-107772807 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 49.71 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6JOlaHsd

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to immediate cutaneous hypersensitivity (ICHS) compared to A/J. (J:63737)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63737

(C57BL/6J x A/J)F1 mice were backcrossed to C57BL/6JOlaHsd mice and the offspring were immunized with birch pollen extract in an effort to scan for loci responsible for immediate cutaneous hypersensitivity. Mapping progentiors A/J and C57BL/6J are low and high responders respectively. 89 offspring were informative to show an association of the hypersensitivity phenotype (symbol Ichs) with D6Mit105 with a LOD score of 2.5.

References

• Original: J:63737 Daser A, et al., Genetics of atopy in a mouse model: polymorphism of the IL-5 receptor alpha chain. Immunogenetics. 2000 Jul;51(8-9):632-8
• All: 1 reference(s)