Il7^tm1Hms
Targeted Allele Detail

Summary

• Symbol: Il7^tm1Hms
• Name: interleukin 7; targeted mutation 1, Harvard Medical School
• MGI ID: MGI:2156458
• Gene: Il7 Location: Chr3:7637088-7678820 bp, - strand Genetic Position: Chr3, 2.02 cM
• Alliance: Il7^tm1Hms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43971
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance construct was inserted into the EcoRI site of exon 2. This mutation inactivates exon 2 and appears to be null. Ribonuclease protection assays detected no transcript from the thymus or spleen of homozygous mutant animals. (J:43971)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il7 Mutation: 33 strains or lines available

References

• Original: J:43971 Rich BE, Autocrine expression of interleukin-7 rescues lymphoid expansion in interleukin-7-deficient mice. Immunology. 1997 Nov;92(3):374-80
• All: 3 reference(s)