Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Candidate Genes
Several skin tumor susceptibility QTLs (Skts1-Skts13) were previously identified in a population of (NIH/Ola x M. spretus)F1 x NIH/Ola backcross animals. In this study the association of allele-specific mutations at the Skts intervals was examined in skin carcinoma samples. Several loci displayed allelic loss or duplication in skin carcinomas. Mapping and Phenotype information for this QTL, its variants and associated markersJ:59049Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH/Ola female x M. spretus male)F1 female mice mated back to NIH/Ola male mice. Using negative binomial regression analysis, suggestive linkage of Skts11 with D6Mit97 (lod 3.17) was observed on mouse Chromosome 6. Skts11 confers susceptibility to either papilloma or carcinoma development in M. spretus. Another locus, Skts12 on mouse Chromosome 6 near D6Mit15 was also correlated with survival time, however the same phenotype may be encoded for by QTLs Skts11 and Skts12. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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