Epha4^tm1Byd
Targeted Allele Detail

Summary

• Symbol: Epha4^tm1Byd
• Name: Eph receptor A4; targeted mutation 1, Andrew W Boyd
• MGI ID: MGI:2156472
• Synonyms: Epha4^-, Epha4^KO
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^tm1Byd page

Disruption of spinal cord architecture and the anterior commissure in Epha4^tm1Byd/Epha4^tm1Byd mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50573
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 3, corresponding to nucleotides 217-880 of the encoded transcript. Immunohistochemical analysis on E8.5 embryos demonstrated that the encoded protein was not detectable in rhomdomeres of homozygous mice. (J:50573)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:50573 Dottori M, et al., EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13248-53
• All: 41 reference(s)