Bcl2l11^tm1.1Jad
Targeted Allele Detail

Summary

• Symbol: Bcl2l11^tm1.1Jad
• Name: BCL2 like 11; targeted mutation 1.1, Jerry M Adams
• MGI ID: MGI:2156483
• Synonyms: bim-beta-gal
• Gene: Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
• Alliance: Bcl2l11^tm1.1Jad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73316
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: Insertion of a floxed PGK-neomycin resistance cassette removed the first three coding exons and placed a lacZ gene under the control of the endogenous promoter. This allele is a derivative of Bcl2l11^tm1Jad in which subsequent Cre-mediated recombination in vivo removed the neo cassette in the germline. The final allele has a single loxP site in place of the three exons. Intense beta-galactosidase staining was detected in the mesenchyme of the metanephric cap of E13.5 heterozygous embryos. (J:73316)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l11 Mutation: 36 strains or lines available

References

• Original: J:73316 Bouillet P, et al., Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim. Dev Cell. 2001 Nov;1(5):645-53
• All: 4 reference(s)