Mbtps1^tm1.1Jdh
Targeted Allele Detail

Summary

• Symbol: Mbtps1^tm1.1Jdh
• Name: membrane-bound transcription factor peptidase, site 1; targeted mutation 1.1, Jay D Horton
• MGI ID: MGI:2156485
• Synonyms: S1P^-
• Gene: Mbtps1 Location: Chr8:120234895-120285474 bp, - strand Genetic Position: Chr8, 67.85 cM, cytoband E1
• Alliance: Mbtps1^tm1.1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72930
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is a derivative of Mbtps1^tm1Jdh. Mice carrying the Mbtps1^tm1Jdh allele were mated to mice carrying a transgene expressing Cre recombinase in the male germline. Progeny of this cross were screened for deletion of exon 2, the neomycin selection cassette and flanking intronic sequences in all tissues. (J:72930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbtps1 Mutation: 73 strains or lines available

References

• Original: J:72930 Yang J, et al., Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13607-12
• All: 1 reference(s)