Atrn^mg-L
Spontaneous Allele Detail

Summary

• Symbol: Atrn^mg-L
• Name: attractin; mahogany Leicester
• MGI ID: MGI:2156486
• Gene: Atrn Location: Chr2:130748415-130872253 bp, + strand Genetic Position: Chr2, 63.26 cM
• Alliance: Atrn^mg-L page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

Allele Type: Spontaneous Mutation: Transposon insertion Mutation details: This allele comprises a 5 kb insertion in intron 27 in a 5' to 3' orientation downstream of the exons encoding the transmembrane domain. The insertion was identified as an intracisternal A particle (IAP) transposon. Northern analysis shows reduced levels of normal message and Western analysis shows reduced levels of normal protein in homozgous mice. (J:71075) Inheritance: Recessive

Schematic of the location of the IAP insertion generating the Atrn^mg-L allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atrn Mutation: 90 strains or lines available

References

• Original: J:53415 Gunn TM, et al., The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999 Mar 11;398(6723):152-6
• All: 3 reference(s)