Agtr1a^tm1Afu
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1Afu
• Name: angiotensin II receptor, type 1a; targeted mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:2156487
• Synonyms: AT1-, AT1a-, AT1A-KO, AT1aR-, AT1KO, AT1-R KO, ATKO, mAT1a^-
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1Afu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28041
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless lacZ gene followed by a neomycin selection cassette replaced the entire coding sequence of the gene. Northern blot analysis demonstrated that no wild-type transcript was produced from this allele. Immunohistochemical analysis indicated that beta-galactosidase was expressed from this allele in the renal cortex of homozygous mice. (J:28041)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

References

• Original: J:28041 Sugaya T, et al., Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem. 1995 Aug 11;270(32):18719-22
• All: 61 reference(s)