Alox5ap^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Alox5ap^tm1Bhk
• Name: arachidonate 5-lipoxygenase activating protein; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:2156546
• Synonyms: 5LO-deficient, FLAP-
• Gene: Alox5ap Location: Chr5:149201814-149224963 bp, + strand Genetic Position: Chr5, 89.18 cM, cytoband G3
• Alliance: Alox5ap^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39229
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 800bp genomic fragment containing sequences encoding amino acids 108-151 was replaced with a neomycin selection cassette. Northern blot analysis indicated that no transcript was produced from this allele. (J:39229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alox5ap Mutation: 15 strains or lines available

References

• Original: J:39229 Byrum RS, et al., Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. J Exp Med. 1997 Mar 17;185(6):1065-75
• All: 3 reference(s)