Amhr2^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Amhr2^tm1Bhr
• Name: anti-Mullerian hormone type 2 receptor; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:2156555
• Synonyms: Misr2^-
• Gene: Amhr2 Location: Chr15:102353802-102363068 bp, + strand Genetic Position: Chr15, 57.58 cM
• Alliance: Amhr2^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36027
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.4 kb genomic fragment containing the first six exons was deleted and replaced with a neomycin selection cassette. RT-PCR analysis demonstrated that no transcript was detectable in the urogenital ridge of homozygous E13.5 embryos. (J:36027)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amhr2 Mutation: 29 strains or lines available

References

• Original: J:36027 Mishina Y, et al., Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev. 1996 Oct 15;10(20):2577-87
• All: 4 reference(s)