Pas14^A/J
QTL Variant Detail

Summary

• QTL variant: Pas14^A/J
• Name: pulmonary adenoma susceptibility 14; A/J
• MGI ID: MGI:2156573
• QTL: Pas14 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:3876

Eighty seven progeny from a (A/J x C3H/He)F2 intercross were analyzed to map the following loci to mouse Chromosome 6: Met - Mtv23 - Cd8b1 - D6Mit10 - Raf1 - D6Mit13a - D6Mit14 - Pas1 - Kras - D6Int1. Only male progeny used. Authors map the QTL for a majorlung tumor susceptibilty gene (Pas1) between D6Mit10 and D6Int1 on mouse Chromosome 6 using linkage analysis of lung tumor susceptibilty in a (A/J x C3H/He)F2 intercross. Significant p values (0.0001) were obtained between Pas1 and D6Mit13, D6Mit14, Kras and D6Int1. Authors state Mtv23 had been previously reported to be near Cd8b1, however this study places it 1 cM distal to Met.

1.28.2016 Curator Note: Because Pas1 was mapped using AXB, BXA and (C57BL/6J x A/J)F2 mice, which differ from the mapping population used here, we condiser the current study a separate mapping experiment and have named this Pas14.

References

• Original: J:3876 Gariboldi M, et al., A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat Genet. 1993 Feb;3(2):132-6
• All: 1 reference(s)