Wrn^tm1Led
Targeted Allele Detail

Summary

• Symbol: Wrn^tm1Led
• Name: Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder
• MGI ID: MGI:2156622
• Synonyms: Wrn^deltahel, WS
• Gene: Wrn Location: Chr8:33724412-33875555 bp, - strand Genetic Position: Chr8, 20.3 cM, cytoband A4
• Alliance: Wrn^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48424
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin selection cassette. The targeted allele is expected to express a fully translated protein that lacks 121 amino acids of the helicase domain. (J:48424)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Wrn^tm1Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wrn Mutation: 94 strains or lines available

References

• Original: J:48424 Lebel M, et al., A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102
• All: 17 reference(s)