Sluc3^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc3^B10.O20/Dem
• Name: susceptibility to lung cancer 3; B10.O20/Dem
• MGI ID: MGI:2156629
• QTL: Sluc3 Location: Chr6:104480321-127019938 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 54.79 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Susceptibility/resistance to lung tumors depends upon interactive effects involving Sluc3 and Sluc4.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36997

Lung tissue of N-ethyl-N-nitrosourea treated F2 progeny of an (OcB-9/Dem x O20/A)F1 intercross was microscopically analyzed for the presence and size of tumors. The progeny were genotyped by PCR. Statistical analysis indicated the presence of a locus influencing susceptibility to lung cancer (Sluc3) on mouse Chromosome 6. The QTL likelihood plot indicates a peak between D2Mit36 and D6Mit218, proximal to the Kras2 locus. The following order of loci was reported: D6Mit21 - D6Mit36 - Sluc3 - D6Mit218 - D6mMit52 - Kras.

References

• Original: J:36997 Fijneman RJ, et al., Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat Genet. 1996 Dec;14(4):465-7
• All: 1 reference(s)