Pas17^{M. spretus}
QTL Variant Detail

Summary

• QTL variant: Pas17^{M. spretus}
• Name: pulmonary adenoma susceptibility 17; M. spretus
• MGI ID: MGI:2156631
• QTL: Pas17 Location: Chr6:124334273-145601739 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: M. spretus

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to lung tumorigenesis compared to C57BL/6J. (J:29218)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29218

Analysis of male progeny from a (A/J x M. spretus)F1 x C57BL/6JBy backcross were analyzed. Interval mapping and quantitative trait linkage was used to map Pas1 to a 18 cM region on mouse Chromosome 6 between marker D6Mit12 and the cosegregating markers Kras, D6Mit14, D6Mit15 and D6Int1.

12.15.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas17.

Susceptibility to lung carcinogenesis was attributed to the mice carrying the A/J allele. Pas17 peaked at Kras2 with a LOD score higher than 8.0; accounting for 34% of the total phenotypic variablity.

References

• Original: J:29218 Manenti G, et al., Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2. Genomics. 1995 Sep 20;29(2):438-44
• All: 1 reference(s)