Fglu^KK/TaJcl
QTL Variant Detail

Summary

• QTL variant: Fglu^KK/TaJcl
• Name: fasting glucose; KK/TaJcl
• MGI ID: MGI:2156633
• QTL: Fglu Location: Chr6:34711598-34711719 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 15.12 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: KK/TaJcl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased fasting plasma glucose levels compared to C57BL/6Jcl. (J:51880)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 6, Smo (7.2 cM) and Flnc (8.5 cM) both show differential expression between restricted and unrestricted diets on the A/a background as well as differential expressionbetween A/a and A/A^vy animals on the restricted diet. D6Wsu176e (2 cM) shows differential expression between restricted and unrestricted diets on the A/A^vy background. Diabesity QTLs Fglu (16 cM), Mob2 (3.05 cM), and Bwtq3 (4 cM) maps near these candidate genes. Candidate genes for diabesity QTLs Nidd3n (35.5 cM), Obq13 (26.8 cM), Obq14 (43.5 cM), and Bw18 (35 cM) are Mad2l1 (30.3 cM) and Rab11fip5 (35.5 cM, formerly ERATO DOI 32e). Mad2l1 shows differential expression between A/a and A/A^vy animalsonboth the restricted and unrestricted diets. Rab11fip5 shows differential expression between A/a and A/A^vy animals on the restricted diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51880

192 (C57BL/6Jcl x KK.B6-A^y/Jcl)F2 intercross animals were typed for 97 polymorphic markers to identify QTLs associated with hyperglycemia and impaired glucose tolerance. Fglu, a QTL significantly associated with fasting glucose levels in a/a F2 animals, mapped to mouse chromosome 6 at approximately 16 cM with a QTL range from 0.68 - 29 cM and LOD = 6 at D6Mit268. Candidate genes in the region of Fglu are the leptin gene (Lep) and neuropeptide Y (Npy). Suggestive QTLs for fasting glucose levels in a/a F2 animals mapped to mouse chromosomes 3 (LOD = 2.8 at D3Mit102), 5 (LOD = 2.8 at D5Mit113), and 14 (LOD = 3.0 at D14Mit165). A suggestive QTL for fasting glucose in A^y/a F2 animals mapped to mouse chromosome 9 at D9Mit229 with a LOD score of 2.8. Suggestive QTLs for glucose tolerance in A^y/a F2 animals mapped to mouse chromosomes 1 (LOD = 2.8 at D1Mit303) and 8 (LOD = 3.0 at D8Mit191).

References

• Original: J:51880 Suto J, et al., Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol. 1998 Dec;139(6):654-61
• All: 1 reference(s)