Trp53^tm1.1Brn
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Brn
• Name: transformation related protein 53; targeted mutation 1.1, Anton Berns
• MGI ID: MGI:2156651
• Synonyms: p53^DEL2-10, Trp53^delta2-10
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73028
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Trp53^tm1Brn in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying the TgN(CMV-Cre)1Cgn transgene. (J:73028)

Expression

In Mice Carrying this Mutation:	31 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
• All: 24 reference(s)