Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
This allele is consistent with a dominant or additive mode of inheritance.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:17972Morphine consumption was assessed in 606 F2 mice from a C57BL/6J x DBA/2J intercross. A subset of the 606 progeny were tested for QTL (quantitative trait analysis). An increase in the preference for morphine consumption, Mop1, was mapped between flanking microsatellite markers D6Mit13 and D6Mit15 on Chromosome 6 with a lod score of 15.0. The authors suggest that this QTL may be related to Qui a locus for quinine taste aversion which also maps to Chromosome 6.J:32894Ninety four backcross progeny of a (C57BL/6J x M. spretus)F1 x C57BL/6J cross were mapped for the following loci: D6Mit86, Pon1 - 1.06 +/- 1.058 - Pon2 - 2.128 +/- 1.486 - D6Mit1. An overall order, incorporating data from the Mouse Genome Database (MGD) was reported as follows: Hc6 - Fdpsl10 - D6Mit86 - Sig - Ica1 - Pon1 - Mop1 - Pon2 - D6Mit1 - Col1a2 - Tac1 - Calcr. These genes were said to cover an approximated 5 cM region of the Chromosome. A note added to the paper proof indicates that Pon3, mapped using the same backcross mice, also localized to mouse Chromosome 6 and no recombination between Pon1 and Pon3 was observed. Mop1 was shown mapping with markers more distal then these reported here( J:17972 Berrettini WH, Nat Genet 1994 May;7(1):54-8 ) |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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