Skts16^Car-S
QTL Variant Detail

Summary

• QTL variant: Skts16^Car-S
• Name: skin tumor susceptibility 16; Car-S
• MGI ID: MGI:2156686
• QTL: Skts16 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: Car-S

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to skin tumorigenesis compared to Car-R. (J:68404)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68404

A further refinement of the skin cancer modifier locus Skts1 was conducted in 245 F2 intercross mice derived from outbred mouse strains Car-R and Car-S. Car-R mice are resistant to skin carcinoma whereas Car-S are susceptible. The cross was informative in narrowing the linkage region of Skts1 to approximately 5.5 cMs. A peak of significant linkage was found with markers M-04814 and M-00295. Tyr was included in the interval. Possible candidates for the Skts1 phenotype include Sh3d2c2 and Fzd4. In addition Marker M-00973 was located upstream of M-04814.

04.28.2015 - Curators Note: Because Skts1 was originally mapped in J:27733 in 1995 using an (NIH/Ola female x M. spretus male)F1 x NIH/Ola backcross, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Skts16.

References

• Original: J:68404 Peissel B, et al., Use of intercross outbred mice and single nucleotide polymorphisms to map skin cancer modifier loci. Mamm Genome. 2001 Apr;12(4):291-4
• All: 1 reference(s)