Summary |
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Variant origin |
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Variant description |
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Notes |
Trait Annotation
Candidate Genes
A search for candidate genes was performed using DU6 and DU6i high body weight selection lines and lean unselected lines DUKs and DBA/2. RNA from epididymal fat tissue of 20 males from each line (DU6, DU6i, DUKs and DBA2/J) was pooled for analysis in Affymetrix GeneChips and resulted in the identification of 77 differentially expressed candidate genes. Of these, 14 genes are located in QTLs intervals affecting body weight and abdominal fat weight. Mapping and Phenotype information for this QTL, its variants and associated markersJ:66233QTLs effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i x DBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat percent QTL 9, abdominal fat weight QTL 9, body weight QTL 14, kidney weight QTL 7, molecular weight of quadriceps QTL 1 and liver weight QTL 6 were mapped to mouse Chromosome 7 to cM positions 22, 23, 28, 28, 29, and 32 respectively. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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