Bw14^DU6i
QTL Variant Detail

Summary

• QTL variant: Bw14^DU6i
• Name: body weight QTL 14; DU6i
• MGI ID: MGI:2156707
• QTL: Bw14 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight compared to DBA/2. (J:66233)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bw14 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTLs effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i x DBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat percent QTL 9, abdominal fat weight QTL 9, body weight QTL 14, kidney weight QTL 7, molecular weight of quadriceps QTL 1 and liver weight QTL 6 were mapped to mouse Chromosome 7 to cM positions 22, 23, 28, 28, 29, and 32 respectively.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)