Mwq1^DU6i
QTL Variant Detail

Summary

• QTL variant: Mwq1^DU6i
• Name: molecular weight of quadriceps QTL 1; DU6i
• MGI ID: MGI:2156710
• QTL: Mwq1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased muscle weight compared to DBA/2J. (J:66233)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Mwq1^DU6i/Mwq1^DU6i	involves: DBA/2J * DU6i
ht2	Mwq1^DBA/2J/Mwq1^DU6i	involves: DBA/2J * DU6i

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
muscle	√	√
abnormal muscle morphology	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mwq1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTLs effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i x DBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat percent QTL 9, abdominal fat weight QTL 9, body weight QTL 14, kidney weight QTL 7, molecular weight of quadriceps QTL 1 and liver weight QTL 6 were mapped to mouse Chromosome 7 to cM positions 22, 23, 28, 28, 29, and 32 respectively.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)