Cia7^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Cia7^DBA/1J
• Name: collagen induced arthritis QTL 7; DBA/1J
• MGI ID: MGI:2156731
• QTL: Cia7 Location: Chr7:85365595-112533819 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased arthritis severity compared to C57BL/10SnSg. (J:57012)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57012

To identify collagen-induced arthritis susceptibility loci outside of the MHC, crosses between the DBA/1 and the less susceptible B10.Q strain were analyzed.

Analysis of 224 (B10.Q x DBA/1)F2 mice identified a suggestive, dominant locus, Cia7 on chromosome 7, associated with disease severity (LOD = 2.8) and incidence (p = 0.0065). Figure 2 displays the locus mapping between D7Mit222 and D7Mit234a. The disease promoting allele was dominantly inherited from the DBA/1 strain. Putative candidate genes include the Il4ra locus.

References

• Original: J:57012 Yang HT, et al., Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat. J Immunol. 1999 Sep 1;163(5):2916-21
• All: 2 reference(s)