Pax6^4Neu
Chemically induced Allele Detail

Summary

• Symbol: Pax6^4Neu
• Name: paired box 6; 4, Neuherberg
• MGI ID: MGI:2156741
• Synonyms: ENU-5045
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^4Neu page

Mutation origin

• Strain of Origin: (102 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as a T to C substitution in exon 10, nucleotide position 979. The resulting protein has a Ser to Pro substitution at amino acid position 273. The mutation resides in the homeobox region of the protein. (J:73625)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:63651 Favor J, et al., Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus. Mamm Genome. 2000 Jul;11(7):520-5
• All: 6 reference(s)