Hlq5^MH
QTL Variant Detail

Summary

• QTL variant: Hlq5^MH
• Name: heat loss QTL 5; MH
• MGI ID: MGI:2156747
• QTL: Hlq5 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: MH line

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased heat loss compared to C57BL/6J.
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55483

Authors used a composite base population from four outbred strains (NIH, ICR, CF-1 and CFW) to select for lines showing a difference in heat loss. After 15 generations of selection, the MH line showed higher heat loss, consumed more feed, were leaner and more active than the ML line of mice. C57BL/6J was chosen as the inbred line to create a resource population from a cross between a selection line and an inbred line. Average heat loss and feed intake of the C57BL/6J mice were similar to that of mice from the ML line but their body composition was similar to the MH line. To identify QTLs that are responsible for heat loss and other phenotypes related to energy balance, a complete genome wide scan was conducted in a (MH x C57BL/6J)F2 intercross (n = 560). Regions harboring QTL with the greatest effects were then evaluated in a (MH x ML)F2 intercross (n = 560). A heat loss QTL, Hlq5 (LOD = 4.06, 3.4% 0f residual variance explained) was identified with a peak at 61 cM on Chromosome 7 in the (MH x C57BL/6J)F2 intercross. The MH allele was responsible for increased heat loss.

References

• Original: J:55483 Moody DE, et al., Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice. Genetics. 1999 Jun;152(2):699-711
• All: 1 reference(s)