Scpro1^DBA/2
QTL Variant Detail

Summary

• QTL variant: Scpro1^DBA/2
• Name: stem cell proliferation 1; DBA/2
• MGI ID: MGI:2156754
• QTL: Scpro1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers shorter life span and higher cell cycling compared to C57BL/6. (J:54115)
• Inheritance: Not Specified

Notes

This allele is associated with higher stem cell cycling rates and shorter life span.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:54115

26 BXD recombinant inbred (RI) strains and 12 BXH REI strains (B = C57BL/6J, D = DBA/2J, H = C3H/HeJ) were screened for loci associated with hemopoietic S-phase cell cycling using a mapping panel. C57BL/6J progenitor strain tends to have lower cell cycling times and longer life span whereas progenitor strains DBA/2J and C3H/HeJ tend to have higher cell cycling times and shorter life spans. Scpro1 (stem cell proliferation) and Scpro2, mapped to mouse chromosome 7 at 6 cM (LOD = 3.4 at D7Ncvs38) and mouse chromosome 11 at 31 cM (LOD = 3.2 at D11Ncvs76), respectively, in the BXD RI strains and were confirmed in the BXH RI strains. DBA/2J-derived alleles at Scpro1 and Scpro2 predisposed animals to 25% shorter life spans and higher cell cycling. Scpro3, a locus associated with cell cycling mapped to mouse chromosome 10 at 60 cM (LOD = 3.7 at Iapls2-37) in the BXH RI strains and is located near the Kit1 gene.

References

• Original: J:54115 De Haan G, et al., Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J. 1999 Apr;13(6):707-13
• All: 1 reference(s)