Lorp1^SS
QTL Variant Detail

Summary

• QTL variant: Lorp1^SS
• Name: loss of righting due to propofol 1; SS
• MGI ID: MGI:2156811
• QTL: Lorp1 Location: Chr7:87073979-87142720 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: SS

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased sleep time after Propofol treatment compared to LS. (J:46300)
• Inheritance: Semidominant

Notes

The SS allele appears to be partially dominant over the LS allele.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:46300

Selectively bred long sleep (LS) and short sleep (SS) mice were used to generate 164 F2 intercross and 25 recombinant inbred progeny to localize a quantitative trait locus (QTL) associated with Propofol nuerosensitivity. LS mice exhibit a longer loss of the righting reflex when treated with the drug than do SS mice. A single QTL, called Lorp1, was found in a 2.7 cM interval on mouse Chromosome 7, tightly linked to Tyr. This locus accounted for 80% of the genetic variance between LS and SS RI strains.

References

• Original: J:46300 Simpson VJ, et al., Identification of a genetic region in mice that specifies sensitivity to propofol. Anesthesiology. 1998 Feb;88(2):379-89
• All: 1 reference(s)