Obq1^{EL/SuzSeyFrkJ}
QTL Variant Detail

Summary

• QTL variant: Obq1^{EL/SuzSeyFrkJ}
• Name: obesity QTL 1; EL/SuzSeyFrkJ
• MGI ID: MGI:2156845
• QTL: Obq1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: EL/SuzSeyFrkJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity compared to 129T2/SvEmsJ. (J:33858)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:33858

Loci affecting obesity were mapped in a (129T2/SvEmsJ x EL/Suz)F2 intercross population using QTL analysis and DNA pooling strategy. Parental strain 129T2/SvEmsJ exhibits a lean phenotype whereas parental strain EL/Suz is prone to obesity. Significant linkage to adiposity index (LOD=8.0), percent inguinal fat (LOD=6.1), percent gonadal fat (LOD=8.4), percent retroperitoneal fat (LOD=7.9), body mass index (LOD=5.1), and 16 week body weight (LOD=4.5) was detected at a locus spanning 21 cM - 49 cM on mouse Chromosome 7. This locus was named Obq1 with peak linkage near D7Mit248. EL/Suz-derived alleles confer increased adiposity in a dominant fashion at Obq1. A second locus, Obq2, was detected at 12 cM - 15 cM on mouse Chromosome 1. Obq2 is linked to adiposity index (LOD=4.0) at D1Mit231. 129T2/SvEmsJ-derived alleles confer increased adiposity in a dominant fashion at Obq2.

References

• Original: J:33858 Taylor BA, et al., Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics. 1996 Jun 15;34(3):389-98
• All: 1 reference(s)