Eae4^ABH
QTL Variant Detail

Summary

• QTL variant: Eae4^ABH
• Name: experimental allergic encephalomyelitis susceptibility 4; ABH
• MGI ID: MGI:2156869
• QTL: Eae4 Location: Chr7:19147398-141919804 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 54.52 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: ABH

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE susceptibility compared to NOD. (J:29171)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29171

The segregation of genes that may contribute to the susceptibility of experimental allergic encephalomyelitis in mice was analyzed in (ABH x NOD)F1 x NOD backcross mice. In a genome wide scan including all autosomes and the X-Chromosome a total of 100 microsatellites were examined.

Significant association of Eae4 with mouse Chromosome 7 was indicated and included a region defined by the proximal locus D7Nds6 and the distal locus D7Mit14.

References

• Original: J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
• All: 1 reference(s)