Csf3r^tm1Eur
Targeted Allele Detail

Summary

• Symbol: Csf3r^tm1Eur
• Name: colony stimulating factor 3 receptor; targeted mutation 1, Erasmus University Rotterdam
• MGI ID: MGI:2156882
• Synonyms: gcsfrdelta715
• Gene: Csf3r Location: Chr4:125918343-125938233 bp, + strand Genetic Position: Chr4, 59.77 cM
• Alliance: Csf3r^tm1Eur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48503
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A nonsense mutation was introduced into the mouse gene at codon 715 by homologous recombination. The mutation is equivalent to that identified in humans with severe chronic neutropenia (SCN). (J:48503)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csf3r Mutation: 42 strains or lines available

References

• Original: J:48503 Hermans MH, et al., Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood. 1998 Jul 1;92(1):32-9
• All: 3 reference(s)